Specific premature epigenetic aging of cartilage in osteoarthritis
Identifieur interne : 000200 ( Main/Exploration ); précédent : 000199; suivant : 000201Specific premature epigenetic aging of cartilage in osteoarthritis
Auteurs : Laura Vidal-Bralo [Espagne] ; Yolanda Lopez-Golan [Espagne] ; Antonio Mera-Varela [Espagne] ; Ignacio Rego-Perez [Espagne] ; Steve Horvath [États-Unis] ; Yuhua Zhang [Canada] ; Álvaro Del Real [Espagne] ; Guangju Zhai [Canada] ; Francisco J. Blanco [Espagne] ; Jose A. Riancho [Espagne] ; Juan J. Gomez-Reino [Espagne] ; Antonio Gonzalez [Espagne]Source :
- Aging (Albany NY) [ 1945-4589 ] ; 2016.
Abstract
Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, suggesting a systemic component of premature aging in the pathogenesis of OA. Here, we have explored epigenetic aging in OA at the local (cartilage and bone) and systemic (blood) levels. Two DNA methylation age-measures (DmAM) were used: the multi-tissue age estimator for cartilage and bone; and a blood-specific biomarker for blood. Differences in DmAM between OA patients and controls showed an accelerated aging of 3.7 years in articular cartilage (95 % CI = 1.1 to 6.3,
Url:
DOI: 10.18632/aging.101053
PubMed: 27689435
PubMed Central: 5076459
Affiliations:
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M. Valdecilla-IDIVAL, University of Cantabria, Cardenal Herrera Oria, 39011, Santander, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Department of Internal Medicine, Hospital U. M. 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Valdecilla-IDIVAL, University of Cantabria, Cardenal Herrera Oria, 39011, Santander, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Department of Internal Medicine, Hospital U. M. Valdecilla-IDIVAL, University of Cantabria, Cardenal Herrera Oria, 39011, Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="Gomez Reino, Juan J" sort="Gomez Reino, Juan J" uniqKey="Gomez Reino J" first="Juan J" last="Gomez-Reino">Juan J. 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Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Laboratorio Investigacion 10 and Rheumatology Unit, Instituto Investigacion Sanitaria, Hospital Clinico Universitario de Santiago, Travesia Choupana, sn. 15706- Santiago de Compostela</wicri:regionArea><wicri:noRegion>sn. 15706- Santiago de Compostela</wicri:noRegion></affiliation></author><author><name sortKey="Lopez Golan, Yolanda" sort="Lopez Golan, Yolanda" uniqKey="Lopez Golan Y" first="Yolanda" last="Lopez-Golan">Yolanda Lopez-Golan</name><affiliation wicri:level="1"><nlm:aff id="A1"> Laboratorio Investigacion 10 and Rheumatology Unit, Instituto Investigacion Sanitaria, Hospital Clinico Universitario de Santiago, Travesia Choupana, sn. 15706- Santiago de Compostela, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Laboratorio Investigacion 10 and Rheumatology Unit, Instituto Investigacion Sanitaria, Hospital Clinico Universitario de Santiago, Travesia Choupana, sn. 15706- Santiago de Compostela</wicri:regionArea><wicri:noRegion>sn. 15706- Santiago de Compostela</wicri:noRegion></affiliation></author><author><name sortKey="Mera Varela, Antonio" sort="Mera Varela, Antonio" uniqKey="Mera Varela A" first="Antonio" last="Mera-Varela">Antonio Mera-Varela</name><affiliation wicri:level="1"><nlm:aff id="A1"> Laboratorio Investigacion 10 and Rheumatology Unit, Instituto Investigacion Sanitaria, Hospital Clinico Universitario de Santiago, Travesia Choupana, sn. 15706- Santiago de Compostela, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Laboratorio Investigacion 10 and Rheumatology Unit, Instituto Investigacion Sanitaria, Hospital Clinico Universitario de Santiago, Travesia Choupana, sn. 15706- Santiago de Compostela</wicri:regionArea><wicri:noRegion>sn. 15706- Santiago de Compostela</wicri:noRegion></affiliation></author><author><name sortKey="Rego Perez, Ignacio" sort="Rego Perez, Ignacio" uniqKey="Rego Perez I" first="Ignacio" last="Rego-Perez">Ignacio Rego-Perez</name><affiliation wicri:level="1"><nlm:aff id="A2"> Grupo de Reumatología, Instituto de Investigación Biomédica de A Coruña, Complexo Hospitalario Universitario de A Coruña, Universidade da Coruña. As Xubias, sn. 15006- A Coruña, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Grupo de Reumatología, Instituto de Investigación Biomédica de A Coruña, Complexo Hospitalario Universitario de A Coruña, Universidade da Coruña. As Xubias, sn. 15006- A Coruña</wicri:regionArea><wicri:noRegion>sn. 15006- A Coruña</wicri:noRegion></affiliation></author><author><name sortKey="Horvath, Steve" sort="Horvath, Steve" uniqKey="Horvath S" first="Steve" last="Horvath">Steve Horvath</name><affiliation wicri:level="1"><nlm:aff id="A3"> Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea> Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095</wicri:regionArea><wicri:noRegion>CA 90095</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Yuhua" sort="Zhang, Yuhua" uniqKey="Zhang Y" first="Yuhua" last="Zhang">Yuhua Zhang</name><affiliation wicri:level="1"><nlm:aff id="A4"> Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, A1B- St. John's, NL, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, A1B- St. John's, NL</wicri:regionArea><wicri:noRegion>NL</wicri:noRegion></affiliation></author><author><name sortKey="Del Real, Alvaro" sort="Del Real, Alvaro" uniqKey="Del Real A" first="Álvaro" last="Del Real">Álvaro Del Real</name><affiliation wicri:level="1"><nlm:aff id="A5"> Department of Internal Medicine, Hospital U. M. Valdecilla-IDIVAL, University of Cantabria, Cardenal Herrera Oria, 39011, Santander, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Department of Internal Medicine, Hospital U. M. Valdecilla-IDIVAL, University of Cantabria, Cardenal Herrera Oria, 39011, Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="Zhai, Guangju" sort="Zhai, Guangju" uniqKey="Zhai G" first="Guangju" last="Zhai">Guangju Zhai</name><affiliation wicri:level="1"><nlm:aff id="A4"> Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, A1B- St. John's, NL, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, A1B- St. John's, NL</wicri:regionArea><wicri:noRegion>NL</wicri:noRegion></affiliation></author><author><name sortKey="Blanco, Francisco J" sort="Blanco, Francisco J" uniqKey="Blanco F" first="Francisco J" last="Blanco">Francisco J. Blanco</name><affiliation wicri:level="1"><nlm:aff id="A2"> Grupo de Reumatología, Instituto de Investigación Biomédica de A Coruña, Complexo Hospitalario Universitario de A Coruña, Universidade da Coruña. As Xubias, sn. 15006- A Coruña, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Grupo de Reumatología, Instituto de Investigación Biomédica de A Coruña, Complexo Hospitalario Universitario de A Coruña, Universidade da Coruña. As Xubias, sn. 15006- A Coruña</wicri:regionArea><wicri:noRegion>sn. 15006- A Coruña</wicri:noRegion></affiliation></author><author><name sortKey="Riancho, Jose A" sort="Riancho, Jose A" uniqKey="Riancho J" first="Jose A." last="Riancho">Jose A. Riancho</name><affiliation wicri:level="1"><nlm:aff id="A5"> Department of Internal Medicine, Hospital U. M. Valdecilla-IDIVAL, University of Cantabria, Cardenal Herrera Oria, 39011, Santander, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Department of Internal Medicine, Hospital U. M. Valdecilla-IDIVAL, University of Cantabria, Cardenal Herrera Oria, 39011, Santander</wicri:regionArea><wicri:noRegion>Santander</wicri:noRegion></affiliation></author><author><name sortKey="Gomez Reino, Juan J" sort="Gomez Reino, Juan J" uniqKey="Gomez Reino J" first="Juan J" last="Gomez-Reino">Juan J. Gomez-Reino</name><affiliation wicri:level="1"><nlm:aff id="A1"> Laboratorio Investigacion 10 and Rheumatology Unit, Instituto Investigacion Sanitaria, Hospital Clinico Universitario de Santiago, Travesia Choupana, sn. 15706- Santiago de Compostela, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Laboratorio Investigacion 10 and Rheumatology Unit, Instituto Investigacion Sanitaria, Hospital Clinico Universitario de Santiago, Travesia Choupana, sn. 15706- Santiago de Compostela</wicri:regionArea><wicri:noRegion>sn. 15706- Santiago de Compostela</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez, Antonio" sort="Gonzalez, Antonio" uniqKey="Gonzalez A" first="Antonio" last="Gonzalez">Antonio Gonzalez</name><affiliation wicri:level="1"><nlm:aff id="A1"> Laboratorio Investigacion 10 and Rheumatology Unit, Instituto Investigacion Sanitaria, Hospital Clinico Universitario de Santiago, Travesia Choupana, sn. 15706- Santiago de Compostela, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea> Laboratorio Investigacion 10 and Rheumatology Unit, Instituto Investigacion Sanitaria, Hospital Clinico Universitario de Santiago, Travesia Choupana, sn. 15706- Santiago de Compostela</wicri:regionArea><wicri:noRegion>sn. 15706- Santiago de Compostela</wicri:noRegion></affiliation></author></analytic><series><title level="j">Aging (Albany NY)</title><idno type="eISSN">1945-4589</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, suggesting a systemic component of premature aging in the pathogenesis of OA. Here, we have explored epigenetic aging in OA at the local (cartilage and bone) and systemic (blood) levels. Two DNA methylation age-measures (DmAM) were used: the multi-tissue age estimator for cartilage and bone; and a blood-specific biomarker for blood. Differences in DmAM between OA patients and controls showed an accelerated aging of 3.7 years in articular cartilage (95 % CI = 1.1 to 6.3, <italic>P</italic> = 0.008) of OA patients. By contrast, no difference in epigenetic aging was observed in bone (0.04 years; 95 % CI = −1.8 to 1.9, <italic>P</italic> = 0.3) and in blood (−0.6 years; 95 % CI = −1.5 to 0.3, <italic>P</italic> = 0.2) between OA patients and controls. Therefore, premature epigenetic aging according to DNA methylation changes was specific of OA cartilage, adding further evidence and insight on premature aging of cartilage as a component of OA pathogenesis that reflects damage and vulnerability.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Murphy, L" uniqKey="Murphy L">L Murphy</name></author><author><name sortKey="Schwartz, Ta" uniqKey="Schwartz T">TA Schwartz</name></author><author><name sortKey="Helmick, Cg" uniqKey="Helmick C">CG Helmick</name></author><author><name sortKey="Renner, Jb" uniqKey="Renner J">JB Renner</name></author><author><name sortKey="Tudor, G" uniqKey="Tudor G">G Tudor</name></author><author><name sortKey="Koch, G" uniqKey="Koch G">G Koch</name></author><author><name sortKey="Dragomir, A" uniqKey="Dragomir A">A Dragomir</name></author><author><name sortKey="Kalsbeek, Wd" uniqKey="Kalsbeek W">WD Kalsbeek</name></author><author><name sortKey="Luta, G" 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uniqKey="Assadzadeh A">A Assadzadeh</name></author><author><name sortKey="Flanagan, J" uniqKey="Flanagan J">J Flanagan</name></author><author><name sortKey="Petronis, A" uniqKey="Petronis A">A Petronis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altman, R" uniqKey="Altman R">R Altman</name></author><author><name sortKey="Alarc N, G" uniqKey="Alarc N G">G Alarcón</name></author><author><name sortKey="Appelrouth, D" uniqKey="Appelrouth D">D Appelrouth</name></author><author><name sortKey="Bloch, D" uniqKey="Bloch D">D Bloch</name></author><author><name sortKey="Borenstein, D" uniqKey="Borenstein D">D Borenstein</name></author><author><name sortKey="Brandt, K" uniqKey="Brandt K">K Brandt</name></author><author><name sortKey="Brown, C" uniqKey="Brown C">C Brown</name></author><author><name sortKey="Cooke, Td" uniqKey="Cooke T">TD Cooke</name></author><author><name sortKey="Daniel, W" uniqKey="Daniel W">W Daniel</name></author><author><name sortKey="Gray, R" uniqKey="Gray R">R Gray</name></author><author><name sortKey="Greenwald, R" uniqKey="Greenwald R">R Greenwald</name></author><author><name sortKey="Hochberg, M" uniqKey="Hochberg M">M Hochberg</name></author><author><name sortKey="Howell, D" uniqKey="Howell D">D Howell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez Lopez, J" uniqKey="Rodriguez Lopez J">J Rodriguez-Lopez</name></author><author><name sortKey="Pombo Suarez, M" uniqKey="Pombo Suarez M">M Pombo-Suarez</name></author><author><name sortKey="Liz, M" uniqKey="Liz M">M Liz</name></author><author><name sortKey="Gomez Reino, Jj" uniqKey="Gomez Reino J">JJ Gomez-Reino</name></author><author><name sortKey="Gonzalez, A" uniqKey="Gonzalez A">A Gonzalez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Faul, F" uniqKey="Faul F">F Faul</name></author><author><name sortKey="Erdfelder, E" uniqKey="Erdfelder E">E Erdfelder</name></author><author><name sortKey="Lang, Ag" uniqKey="Lang A">AG Lang</name></author><author><name sortKey="Buchner, A" uniqKey="Buchner A">A Buchner</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>Espagne</li><li>États-Unis</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Vidal Bralo, Laura" sort="Vidal Bralo, Laura" uniqKey="Vidal Bralo L" first="Laura" last="Vidal-Bralo">Laura Vidal-Bralo</name></noRegion><name sortKey="Blanco, Francisco J" sort="Blanco, Francisco J" uniqKey="Blanco F" first="Francisco J" last="Blanco">Francisco J. Blanco</name><name sortKey="Del Real, Alvaro" sort="Del Real, Alvaro" uniqKey="Del Real A" first="Álvaro" last="Del Real">Álvaro Del Real</name><name sortKey="Gomez Reino, Juan J" sort="Gomez Reino, Juan J" uniqKey="Gomez Reino J" first="Juan J" last="Gomez-Reino">Juan J. Gomez-Reino</name><name sortKey="Gonzalez, Antonio" sort="Gonzalez, Antonio" uniqKey="Gonzalez A" first="Antonio" last="Gonzalez">Antonio Gonzalez</name><name sortKey="Lopez Golan, Yolanda" sort="Lopez Golan, Yolanda" uniqKey="Lopez Golan Y" first="Yolanda" last="Lopez-Golan">Yolanda Lopez-Golan</name><name sortKey="Mera Varela, Antonio" sort="Mera Varela, Antonio" uniqKey="Mera Varela A" first="Antonio" last="Mera-Varela">Antonio Mera-Varela</name><name sortKey="Rego Perez, Ignacio" sort="Rego Perez, Ignacio" uniqKey="Rego Perez I" first="Ignacio" last="Rego-Perez">Ignacio Rego-Perez</name><name sortKey="Riancho, Jose A" sort="Riancho, Jose A" uniqKey="Riancho J" first="Jose A." last="Riancho">Jose A. Riancho</name></country><country name="États-Unis"><noRegion><name sortKey="Horvath, Steve" sort="Horvath, Steve" uniqKey="Horvath S" first="Steve" last="Horvath">Steve Horvath</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Zhang, Yuhua" sort="Zhang, Yuhua" uniqKey="Zhang Y" first="Yuhua" last="Zhang">Yuhua Zhang</name></noRegion><name sortKey="Zhai, Guangju" sort="Zhai, Guangju" uniqKey="Zhai G" first="Guangju" last="Zhai">Guangju Zhai</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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